Prognosis of glioblastoma patients improves significantly over time interrogating historical controls - Institut Pierre Louis d'Epidémiologie et de Santé Publique
Article Dans Une Revue (Data Paper) European Journal of Cancer Année : 2024

Prognosis of glioblastoma patients improves significantly over time interrogating historical controls

Résumé

Background: Glioblastoma (GBM) is the most common devastating primary brain cancer in adults. In our clinical practice, median overall survival (mOS) of GBM patients seems increasing over time. Methods: To address this observation, we have retrospectively analyzed the prognosis of 722 newly diagnosed GBM patients, aged below 70, in good clinical conditions (i.e. Karnofsky Performance Status -KPS- above 70%) and treated in our department according to the standard of care (SOC) between 2005 and 2018. Patients were divided into two groups according to the year of diagnosis (group 1: from 2005 to 2012; group 2: from 2013 to 2018). Results: Characteristics of patients and tumors of both groups were very similar regarding confounding factors (age, KPS, MGMT promoter methylation status and treatments). Follow-up time was fixed at 24 months to ensure comparable survival times between both groups. Group 1 patients had a mOS of 19 months ([17.3-21.3]) while mOS of group 2 patients was not reached. The recent period of diagnosis was significantly associated with a longer mOS in univariate analysis (HR=0.64, 95% CI [0.51 - 0.81]), p < 0.001). Multivariate Cox analysis showed that the period of diagnosis remained significantly prognostic after adjustment on confounding factors (adjusted Hazard Ratio (aHR) 0.49, 95% CI [0.36-0.67], p < 0.001). Conclusion: This increase of mOS over time in newly diagnosed GBM patients could be explained by better management of potentially associated non-neurological diseases, optimization of validated SOC, better management of treatments side effects, supportive care and participation in clinical trials.
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Dates et versions

hal-04627071 , version 1 (13-09-2024)

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A. Thomas, S. Tran, L. El Houari, A. Seyve, F. Bielle, et al.. Prognosis of glioblastoma patients improves significantly over time interrogating historical controls. European Journal of Cancer, 2024, 202, pp.114004. ⟨10.1016/j.ejca.2024.114004⟩. ⟨hal-04627071⟩
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