Acetylcholinesterase deficiency Glucocorticoid-receptor Cell penetrating peptide Gene editing Myotonic dystrophy CRISPRi Cardiac muscle MBNL Diaphragm Mouse model Therapy ARN Muscle Alternative splicing CMS Autophagy Exercice ACETYLCHOLINESTERASE Thérapie génique Dystrophie Myotonique Astrocyte Myotonic dystrophy type 1 Gene Therapy BIOLOGIE MOLECULAIRE PacBio Neuron Glutamate Myotonic Dystrophy Type 1 Intermediate filament KNOCKOUT MICE Animals Mouse models Fibrosis Humans Glucocorticoids Mice Glial cells Maximal force Myelin Brain Brain dysfunction Knockout DM1 Quantitative microdialysis Astrocytes Trinucleotide Repeat Expansion Cell model Hypoxia Dynamin 2 Duchenne muscular dystrophy Transgenic mouse Myotonic Dystrophy In vivo Exercise Motoneuron Aging Skeletal muscle Dystrophin RNA splicing Dilated cardiomyopathy RNA biology Oligodendrocytes Dystrophie myotonique CTG repeat contractions Gene therapy Trinucleotide repeat expansion Long read sequencing Cell culture model Desmin Muscular dystrophy Acute coronary syndrome AAV Genotype phenotype correlation Transgenic mouse model Myotonic dystrophy mouse models Myostatin GABA Acetylcholinesterase knockout mouse DMSXL mice Oligodendrocyte CTG repeats GSK3␤ Heart Cytoskeleton Endurance training Transcriptomics Heart failure Male CONGENITAL MYATHENIC SYNDROME PCR Central nervous system RNA interference CRISPR/Cas9 CTG repeat instability DMPK Centronuclear myopathy Antisense oligonucleotides Antisense oligonucleotide Myotonic Dystrophy type 1 Expression